Last Known Appearance and Immediate Response Nancy Guthrie, 84, vanished Saturday night around 9:30 p.m. from her Catalina Foothills residence near East Skyline Drive and North Campbell Avenue in Tucson; she was alone and did not appear at her church the next morning, prompting her family to file a missing‑person report on Sunday [1][2][3][4][5][6]. Sheriff Chris Nanos publicly stated she “did not walk out of there” and treated the home as a crime scene, an unusual step for a missing‑person case [3][4][5][6]. Deputies secured the property, recovered her cellphone on‑site, and began a coordinated search while urging the public to call a dedicated tip line [1][5][6].

Law Enforcement and Federal Assistance The investigation enlisted homicide detectives, the FBI, Border Patrol, and volunteers, marking a “non‑standard move” by Pima County [1][2]. Technological support from Google, Apple, license‑plate readers, neighborhood cameras, drones, heat‑sensing equipment, and K‑9 units scanned the surrounding desert for clues [1][3][5][6]. Despite numerous leads, officials have not identified a specific suspect or vehicle, and they stress there is no immediate threat to the public [3][5].

Medical Urgency and Reward Nancy Guthrie requires daily medication for mobility issues; the sheriff warned that missing a dose for more than 24 hours could be fatal, and she had been without it for over 30 hours at the time of the press conference [1][2][3][4]. The 88‑Crime nonprofit announced a reward of up to $2,500 for information leading to an arrest, and the sheriff’s office continues to field tips via phone [1][4]. Family members emphasized the critical health risk, heightening the urgency of the search [2][5].

Public Appeals and Media Involvement Savannah Guthrie used her platform on TODAY to thank supporters, request prayers, and ask anyone with information to contact authorities [1][2][4][5][6]. She traveled to Arizona on Monday, missing the morning broadcast, and reiterated the focus on her mother’s safe return [5]. The case has attracted national attention, prompting extensive media coverage and community outreach [3][4].

Minor Discrepancies Among Reports AP highlighted the involvement of Border Patrol and volunteer drones, while Newsweek emphasized heat‑sensing equipment and noted no public danger [2][3]. King5 provided a detailed physical description of Nancy Guthrie but did not disclose her clothing at the time of disappearance [4]. All outlets agree on the crime‑scene designation, the lack of a confirmed suspect, and the critical need for her medication [1][2][3][4][5][6].